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We would like to acknowledge and thank the Napier family and friends for their support of the TDRA. Donations were made in memory of Barry Napier, who passed away on March 13, 2017 after a long battle with dementia.

Validation of the TorCA published in Alzheimer’s Research & Therapy

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News

A new study has uncovered why some people that have brain markers of Alzheimer's disease (AD) never develop the classic dementia that others do. The results showed that resilient individuals had [...]

Scientists have suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer's disease, which could provide new avenues for future research. [...]

Older adults who initiate dialysis for kidney failure face a higher likelihood of being diagnosed with dementia and Alzheimer's disease. Certain risk factors were linked this higher risk. Older h [...]

There is new hope for the treatment of Alzheimer's and other neurological diseases following a ground-breaking discovery. [...]

A study of 3,877 randomly selected patients found a significant link between three degenerative eye diseases -- age-related macular degeneration, diabetic retinopathy and glaucoma -- and Alzheimer [...]

Alzheimer's disease and type 2 diabetes: Hope for inhibitors against amyloid plaquesEffective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available. Scientists have now come a little bit closer to a solution: [...]

pH imbalance in brain cells may contribute to Alzheimer's diseaseScientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline -- or pH -- chemistr [...]

A study by researchers investigated lesser-known molecules involved in tauopathies like Alzheimer's. They focused on microRNAs (miRNAs), gene expression regulators that bind to and destroy protei [...]

Alzheimer's drug may stop disease if used before symptoms develop, study suggestsBiologists have gained new understanding of how Alzheimer's disease begins, and how it might be halted using a current medication. [...]

Microfluidic system incorporates neuroinflammation into 'Alzheimer's in a dish' modelBuilding on their development of the first culture system to replicate fully the pathology behind Alzheimer's disease, a research team has now produced a system that includes neuroinflammation, t [...]

Two new studies illustrate that not all forms of amyloid-beta protein -- the protein thought to initiate Alzheimer's disease -- play an equally menacing role in the progress of the disease. Using [...]

Brain discovery could block aging's terrible toll on the mindAging vessels connecting the brain and the immune system play critical roles in both Alzheimer's disease and the decline in cognitive ability that comes with time, new research reveals. By improv [...]

Reduced levels of plasmalogens are associated with an increased risk of Alzheimer's Disease, according to new research. [...]

Two new studies highlight a significant increase in harmful side effects related to the use of commonly prescribed opioid painkillers in people with dementia. Researchers also identified a mechanism t [...]

The first dementia prevalence data from a large population of lesbian, gay and bisexual older adults was reported today. [...]

Increased frontal brain activity in healthy older adults reflects reduced efficiency rather than a way to maintain cognitive function, finds a study of two human samples. The findings contradict a lea [...]

New research highlights sex differences associated with dementia and Alzheimer's disease across the life course, including the first ever large-scale study of reproductive history and dementia ri [...]

Virtual reality technology gives high school students greater insight into what it's like to be someone with suspected mild cognitive impairment, or someone progressing through the continuum of A [...]

Treating dementia with the healing waves of soundUltrasound waves applied to the whole brain improve cognitive dysfunction in mice with conditions simulating vascular dementia and Alzheimer's disease. It is possible that this type of therapy ma [...]

In adults over 70, exposure to general anesthesia and surgery is associated with a subtle decline in memory and thinking skills, according to new research. The study analyzed nearly 2,000 people and f [...]

A new machine-learning model that scans routinely collected NHS data has shown promising signs of being able to predict undiagnosed dementia in primary care. The results from the feasibility study sug [...]

Majority of older adults with probable dementia are likely unaware they have it, study suggestsAn analysis of information gathered for an ongoing and federally sponsored study of aging and disability adds to evidence that a substantial majority of older adults with probable dementia in the Unit [...]

Researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in [...]

One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' now provides a 3D view of brain molecules with 1 [...]

Authors lament the unmet promise of a miracle drug for Alzheimer disease but are heartened by what they see as encouraging improvements in care (care transformation) for a growing population of older [...]

The secret sulfate code that lets the bad Tau inResearchers have uncovered details of how cells invite inside corrupted proteins that can turn normal proteins corrupt, leading to neurodegenerative diseases such as Alzheimer's and Parkinson [...]

Alzheimer's disease is a progressive, neurodegenerative condition that often begins with mild cognitive impairment (MCI), making early and repeated assessments of cognitive change crucial to diag [...]

Herpes linked to Alzheimer's: Antivirals may helpA new commentary on a study by epidemiologists supports the viability of a potential way to reduce the risk of Alzheimer's disease. When the authors looked at subjects who suffered severe herpes [...]

Contact with greenspace is known to have beneficial effects for mental health. A new study suggests that it may also play a positive role against cognitive decline in elderly. In particular, this rese [...]

The 'Big Bang' of Alzheimer's: Scientists ID genesis of diseaseScientists have discovered a 'Big Bang' of Alzheimer's disease -- the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain. [...]

A new study has found the mechanism by which amyloid beta -- the protein deposited into plaques in the brains of patients with Alzheimer's disease -- protects from the effects of herpes viruses c [...]

The workings of memory and learning have yet to be clarified, especially at the neural circuitry level. But researchers have now discovered a specific brain neuron with a central role in learning. The [...]

Targeting multiple proteins at once may be the real key to treating neurodegenerative diseases, according to a recent study. [...]

Obstructive sleep apnea is associated with changes to the structure of the brain that are also seen in the early stages of dementia, according to a new study. [...]

Scientists have uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people. Studies with rats found the treatment can reverse changes in blood vessels i [...]

A low-dose aspirin regimen may represent a new avenue for reducing Alzheimer's disease pathology, according to new research in a mouse model. The study identifies a new role for one of the most w [...]

Scientists have been successful in mimicking mechanisms of Alzheimer's disease in a novel, stem cell-based model system that reproduces features of human brain tissue. This experimental tool can [...]

A new study suggests that when a high-fat, high-sugar diet that leads to obesity is paired with normal aging, it may contribute to the development of Alzheimer's disease. In addition, researchers [...]

The key to better treatments for brain injuries and disease may lie in the molecules charged with preventing the clumping of specific proteins associated with cognitive decline and other neurological [...]

More evidence for controversial theory that herpesviruses play role in Alzheimer's diseaseIn a large-scale analysis, researchers use data from three different brain banks to suggest that human herpesviruses are more abundant in the brains of Alzheimer's patients and may play a role in [...]

Alzheimer's breakthrough: Brain metals that may drive disease progression revealedAlzheimer's disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition. [...]

The waste-disposal system in a cell can spread harmful protein aggregates between neurons in the brain in Alzheimer's disease. The spread can be reduced in experiments in cultivated cells. The di [...]

A new study indicates that patients with high blood pressure are at a higher risk of developing dementia. This research also shows (for the first time) that an MRI can be used to detect very early sig [...]

People who smoke or have diabetes may be at increased risk of calcifications in a region of the brain crucial to memory, according to a new study. [...]

The rate of decline in certain aspects of memory may be explained by a combination of overall physical fitness and the stiffness of the central arteries. [...]

Researchers reverse cognitive impairments in mice with dementiaReversing memory deficits and impairments in spatial learning is a major goal in dementia research. A lack of knowledge about cellular pathways critical to the development of dementia has prevented si [...]

Active HIV in large white blood cells may drive cognitive impairment in infected miceMacrophages, large white blood cells that engulf and destroy potential pathogens, harbor active viral reserves that appear to play a key role in impaired learning and memory in mice infected with a ro [...]

For more than 20 years, much of the leading research on Alzheimer's has been guided by the 'amyloid hypothesis.' But with a series of failed clinical trials raising questions about this [...]

Dementia, in any form, is a heartbreaking disease that can take away one's thinking and judgement abilities before they pass. To save face, people with dementia often pretend to know answers to q [...]

Short and long daily sleep duration were risk factors for dementia and premature death in a study of Japanese adults aged 60 years and older. [...]