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We would like to acknowledge and thank the Napier family and friends for their support of the TDRA. Donations were made in memory of Barry Napier, who passed away on March 13, 2017 after a long battle with dementia.

Validation of the TorCA published in Alzheimer’s Research & Therapy

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News

Stiffness of the aorta -- more so than blood pressure or subclinical brain disease -- is a key risk factor for dementia. Since aortic stiffness can be reduced by medication and healthy lifestyle chang [...]

Only a small proportion of cases of dementia are thought to be inherited -- the cause of the vast majority is unknown. Now a team of scientists believe they may have found an explanation: spontaneous [...]

New research has revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was fou [...]

A 2016 study showed that exposure to urban pollution involving magnetite particles played a role in the development of Alzheimer's disease. It began from the hypothesis that magnetite particles w [...]

People with a particular kind of irregular heartbeat called atrial fibrillation may experience a faster decline in thinking and memory skills and have a greater risk of dementia than those without atr [...]

In preparation for more tools that detect and measure the biology associated with Alzheimer's and other dementias earlier and with more accuracy, experts have published appropriate use criteria ( [...]

A team of scientists has successfully trained a new artificial intelligence (AI) algorithm to make accurate predictions regarding cognitive decline leading to Alzheimer's disease. [...]

A new study has shown that by combining imaging and neuropsychological testing, one can more accurately assess the cognitive status of individuals. [...]

Periodontal disease bacteria may kick-start Alzheimer'sLong-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer's disease in humans. Periodontal disea [...]

The first large US study of cognition in older breast cancer patients found that within the first two years after diagnosis and treatment, most women do not experience cancer-related cognitive problem [...]

Up to half of people with Alzheimer's disease (AD) use a psychotropic drug, and one in five uses two or more psychotropics concomitantly, according to a new study. [...]

Possible cause for Alzheimer's and traumatic brain injury discoveredA newly identified mechanism explaining the possible cause for Alzheimer's and traumatic brain injury may have also led to the discovery of an effective treatment. [...]

New research reveals that a novel drug reverses memory deficits and stops Alzheimer disease pathology (AD) in an animal model. Importantly, this drug has already proven to be non-toxic for humans in a [...]

For individuals carrying a genetic mutation that causes Alzheimer's disease, engaging in at least 2.5 hours of physical activity per week may have beneficial effects on markers of Alzheimer' [...]

Experts are examining the link between impaired vision, hearing, and cognition. [...]

Leaks in the blood-brain barrier can provide early detection for Alzheimer's and diseases. [...]

Nilvadipine shows no benefit for the treatment of Alzheimer's disease in mild and moderate stages of the disease, but further studies targeting the early phase of the disease may be warranted. [...]

Researchers learn more about the relationship between sexual behavior, function, and cognition (people's ability to think and make decisions). [...]

A vicious feedback loop underlying brain degeneration in Alzheimer's disease may explain why so many drug trials have failed, according to researchers. Their study also identifies a clinically ap [...]

Zombie cells found in brains of mice prior to cognitive lossZombie cells are the ones that can't die but are equally unable to perform the functions of a normal cell. These zombie, or senescent, cells are implicated in a number of age-related diseases. Re [...]

New method enables accurate diagnosis of Alzheimer's diseaseA new brain imaging method can show the spread of specific tau protein depositions, which are unique to cases with Alzheimer's. [...]

Air pollution may be linked to heightened dementia riskAir pollution may be linked to a heightened risk of developing dementia, finds a London-based observational study. The associations found couldn't be explained by factors known to influence the r [...]

Scientists have demonstrated the possibility of detecting dementia from conversations in human-agent interaction. Their research shows how a machine can learn characteristics of sounds of elderly peop [...]

Older adults fitted with a cochlear implant to compensate for severe hearing loss have significantly poorer cognitive function than their normal-hearing counterparts. Hearing loss is a risk factor for [...]

Obesity leads to cognitive impairment by activating microglial cells, which consume otherwise functional synapses in the hippocampus, according to a study of male mice. The research suggests that micr [...]

A study finds that neurogenesis -- inducing the production of new neurons -- in the brain structure in which memories are encoded can improve cognitive function in a mouse model of Alzheimer's di [...]

Analysis of data captured during a long-term study of aging adults shows that those who report being very sleepy during the day were nearly three times more likely than those who didn't to have b [...]

Adults both with and without Alzheimer's disease have better cognition skills in the late summer and early fall than in the winter and spring, according to a new study. [...]

Novel strategy shows promise for earlier detection of Alzheimer's diseaseFinding an effective way to identify people with mild cognitive impairment who are most likely to go on to develop Alzheimer's disease has eluded researchers for years. But now, a team of researc [...]

The study analyzed data on stroke and dementia risk from 3.2 million people across the world. The link between stroke and dementia persisted even after taking into account other dementia risk factors [...]

Researchers have discovered that a modified version of an important immune cell protein could be used to treat Alzheimer's disease. The study reveals that soluble versions of a protein called TLR [...]

A clock drawing test for detecting cognitive dysfunction should be conducted routinely in patients with high blood pressure, according to new research. [...]

A new study finds that four out of 10 patients with atrial fibrillation but no history of stroke or transient ischemic attack have previously unknown brain damage. [...]

A psychologist found that carriers of a gene variant that increases the risk for Alzheimer's disease have greater difficulty describing detailed memories of past events. The goal of his research [...]

Alzheimer's one day may be predicted during eye examUsing technology similar to what is found in many eye doctors' offices, researchers have detected evidence suggesting Alzheimer's in older patients who had no symptoms of the disease. [...]

Tau protein accumulation is common across 20 human brain diseases. Researchers have found stressed, senescent cells in Alzheimer's disease, and established a link between tau tangles and this cel [...]

Osteoporosis is estimated to affect 200 million women across the world. In recent decades, several authors have analyzed the impact of osteoporosis on the risk of cognitive decline. [...]

A new study has uncovered why some people that have brain markers of Alzheimer's disease (AD) never develop the classic dementia that others do. The results showed that resilient individuals had [...]

Scientists have suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer's disease, which could provide new avenues for future research. [...]

Older adults who initiate dialysis for kidney failure face a higher likelihood of being diagnosed with dementia and Alzheimer's disease. Certain risk factors were linked this higher risk. Older h [...]

There is new hope for the treatment of Alzheimer's and other neurological diseases following a ground-breaking discovery. [...]

A study of 3,877 randomly selected patients found a significant link between three degenerative eye diseases -- age-related macular degeneration, diabetic retinopathy and glaucoma -- and Alzheimer [...]

Alzheimer's disease and type 2 diabetes: Hope for inhibitors against amyloid plaquesEffective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available. Scientists have now come a little bit closer to a solution: [...]

pH imbalance in brain cells may contribute to Alzheimer's diseaseScientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline -- or pH -- chemistr [...]

A study by researchers investigated lesser-known molecules involved in tauopathies like Alzheimer's. They focused on microRNAs (miRNAs), gene expression regulators that bind to and destroy protei [...]

Alzheimer's drug may stop disease if used before symptoms develop, study suggestsBiologists have gained new understanding of how Alzheimer's disease begins, and how it might be halted using a current medication. [...]

Microfluidic system incorporates neuroinflammation into 'Alzheimer's in a dish' modelBuilding on their development of the first culture system to replicate fully the pathology behind Alzheimer's disease, a research team has now produced a system that includes neuroinflammation, t [...]

Two new studies illustrate that not all forms of amyloid-beta protein -- the protein thought to initiate Alzheimer's disease -- play an equally menacing role in the progress of the disease. Using [...]

Brain discovery could block aging's terrible toll on the mindAging vessels connecting the brain and the immune system play critical roles in both Alzheimer's disease and the decline in cognitive ability that comes with time, new research reveals. By improv [...]

Reduced levels of plasmalogens are associated with an increased risk of Alzheimer's Disease, according to new research. [...]