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We would like to acknowledge and thank the Napier family and friends for their support of the TDRA. Donations were made in memory of Barry Napier, who passed away on March 13, 2017 after a long battle with dementia.

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News

A new study proposes that the presence of two beta-amyloid molecules bound together (beta-amyloid dimers) could provide a new biomarker for AD. [...]

Using two complementary approaches to reduce the deposits of amyloid-beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer's dis [...]

Losing just one night of sleep led to an immediate increase in beta-amyloid, a protein in the brain associated with Alzheimer's disease, according to a small, new study. [...]

Studies show that too much sitting, like smoking, increases the risk of heart disease, diabetes and premature death. Researchers found sedentary behavior is linked to thinning in regions of the brain [...]

Inflammatory reactions can change the brain's immune cells in the long term -- meaning that these cells have an 'immunological memory.' This memory may influence the progression of neur [...]

Researchers propose shifting the definition of Alzheimer's disease in living people -- for use in research -- from the current one, based on cognitive changes and behavioral symptoms with biomark [...]

Scientists fix genetic risk factor for Alzheimer's disease in human brain cellsResearchers have revealed how apoE4 confers its risk for Alzheimer's disease in human brain cells. What's more, they were able to erase the damage caused by apoE4 by changing it, with a smal [...]

The use of antiepileptic drugs is associated with an increased risk of Alzheimer's disease and dementia, according to a new study. Continuous use of antiepileptic drugs for a period exceeding one [...]

Controlling blood pressure with any of the commonly prescribed antihypertensive medications (beta blockers, ACE inhibitors, calcium channel blocks, and diuretics) can prevent dementia in older African [...]

Alzheimer's disease is thought to begin long before patients show typical symptoms like memory loss. Scientists have now developed a blood test for Alzheimer's disease and found that it can [...]

A recent study suggests that training programs can help, but only if they are tailored towards an individual's specific memory difficulty, such as trouble remembering faces, voices or recent even [...]

Scientists provide evidence that a long-term consumption of caffeine has negative effects for Alzheimer’s disease, worsening the neuropsychiatric symptoms appearing in the majority of those affected b [...]

Antibody removes Alzheimer's plaques, in micePlaques of a brain protein called amyloid beta are a characteristic sign of Alzheimer's disease. But nestled within the plaques are small amounts of another Alzheimer's protein: APOE. Now, r [...]

Initiating an opioid analgesic reduced the use of antipsychotics and benzodiazepines in persons with Alzheimer's disease, a recent study shows. These drugs are frequently prescribed to treat beha [...]

Because there's currently no cure for dementia, it's important to know about risk factors that may lead to developing it. For example, researchers have learned that older adults with slower [...]

Mutations of the bassoon gene causing new brain disorderNewly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking. [...]

The neurodegenerative condition known as Alzheimer's disease is the commonest cause of dementia. A research group led by molecular biologists have investigated changes in certain lipids (choline [...]

Alzheimer's disease is most often characterized by two different pathologies in the brain: plaque deposits of a protein called beta-amyloid and tangles of another protein called tau. A new articl [...]

A new study in mice provides new clues about how a class of anti-rejection drugs used after organ transplants may also slow the progression of early-stage Alzheimer's disease. [...]

Vegetable compound could have a key role in 'beeting' Alzheimer's diseaseA compound in beets that gives the vegetable its distinctive red color could help slow the accumulation of misfolded proteins in the brain, a process associated with Alzheimer's disease. Scientis [...]

Women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia decades later, compared to women who were moderately fit, according to a new study. The study meas [...]

African Americans with a common genetic variation are at increased risk for developing Alzheimer's disease, while European Americans with the same variation are not, according to a new study. [...]

The largest genetic study of stroke to date triples the number of known genetic risk factors for the disease and also should enable researchers to find novel treatments for dementia. [...]

As we get older, it's not uncommon to experience 'senior moments,' in which we forget where we parked our car or call our children by the wrong names. And we may wonder: Are these memor [...]

Medical researchers have identified novel biomarkers of risk for future dementia. [...]

Treatments targeted to enhance brain neurotrophic factor signaling could improve memory functions in Alzheimer's disease even though they don't alter brain amyloid burden, according to recen [...]

'Epigenetic landscape' is protective in normal aging, impaired in Alzheimer's diseaseResearchers profiled the epigenomic landscape of Alzheimer's brains, specifically in one of the regions affected early in AD, the lateral temporal lobe. They compared these to both younger and el [...]

For the first time, scientists have determined that an Alzheimer's disease (AD) polygenic risk score can be used to correctly identify adults with mild cognitive impairment (MCI) who were only in [...]

Stem-cell study points to new approach to Alzheimer's diseaseImproving the trafficking of brain-cell proteins to reduce toxic buildup holds possibilities for new therapies against Alzheimer's disease. [...]

Brain injury may boost risk of Alzheimer's earlier in lifeConcussions and other traumatic brain injuries may increase the risk of developing Alzheimer's disease earlier in life, according to a new study. [...]

A new study shows that the closer a person gets to the age at which their parent exhibited the first signs of Alzheimer's, the more likely they are to have amyloid plaques, the cause of the cogni [...]

Patients may score slightly lower on certain memory tests after having surgery and anesthesia. [...]

Largest study of its kind finds alcohol use biggest risk factor for dementiaAlcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study of ove [...]

Protein levels in spinal fluid correlate to posture and gait difficulty in Parkinson'sLevels of a protein found in the brain called alpha-synuclein are significantly lower than normal in cerebrospinal fluid collected in Parkinson's disease patients suffering from postural instabil [...]

Data detectives shift suspicions in Alzheimer's from usual suspect to inside villainThe pursuit of the usual suspect in Alzheimer's research may be distracting from a more direct culprit in the disease, according to a study that analyzed data from 51 published experiments. P-tau [...]

Doctors who work with individuals at risk of developing dementia have long suspected that patients who do not realize they experience memory problems are at greater risk of seeing their condition wors [...]

Amyloid protein transmission through neurosurgeryAmyloid beta pathology -- protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new study. Researchers studied the medical records of four p [...]

Poor fitness linked to weaker brain fiber, higher dementia riskScientists have more evidence that exercise improves brain health and could be a lifesaving ingredient that prevents Alzheimer's disease. [...]

Alzheimer's disease reversed in mouse modelResearchers have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease, thereby improving the a [...]

New research has found that pimavanserin significantly improves psychosis symptoms in people with Alzheimer's disease, without the devastating side-effects of currently used antipsychotics. The r [...]

A new study suggests an association between overactive and cytosolic BRCA1, the major guardian of genomic stability, and neurons death in Alzheimer's disease (AD). Upregulated BRCA1 is associated [...]

After more than a decade of research, this much we know: it's good for your brain to know another language. A new study goes further, however, focusing specifically on the effects of knowing a se [...]

Study offers new insights into how brain and rest of body communicate. [...]

Half of all dementias start with damaged 'gatekeeper cells'Research sheds new light on how a breakdown in the brain's vascular system predates the accumulation of toxic plaques and tangles in the brain that bring about Alzheimer's disease. The resea [...]

Low levels of alcohol good for the brain, study showsWhile a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well. The new study shows that low levels of alcohol consumpt [...]

Traumatic brain injuries increase the risk of a dementia diagnosis for more than 30 years after a trauma, though the risk of dementia decreases over time, according to a new study. [...]

Brain pacemaker study shows promise in slowing decline of Alzheimer'sResearchers have studied how using an implant -- likened to a pacemaker for the brain -- could help Alzheimer's patients to retain cognitive, behavioral and functional abilities longer while also [...]

People with Alzheimer’s disease have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder. Researchers have found that such circ [...]

A diet created by researchers may help substantially slow cognitive decline in stroke survivors, according to preliminary research. The finding are significant because stroke survivors are twice as li [...]

Enhanced lifestyle counselling prevents cognitive decline even in people who are carriers of the APOE4 gene, a common risk factor of Alzheimer's disease, according to a new study. [...]