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We would like to acknowledge and thank the Napier family and friends for their support of the TDRA. Donations were made in memory of Barry Napier, who passed away on March 13, 2017 after a long battle with dementia.

Validation of the TorCA published in Alzheimer’s Research & Therapy

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News

A vicious feedback loop underlying brain degeneration in Alzheimer's disease may explain why so many drug trials have failed, according to researchers. Their study also identifies a clinically ap [...]

Zombie cells found in brains of mice prior to cognitive lossZombie cells are the ones that can't die but are equally unable to perform the functions of a normal cell. These zombie, or senescent, cells are implicated in a number of age-related diseases. Re [...]

New method enables accurate diagnosis of Alzheimer's diseaseA new brain imaging method can show the spread of specific tau protein depositions, which are unique to cases with Alzheimer's. [...]

Scientists have demonstrated the possibility of detecting dementia from conversations in human-agent interaction. Their research shows how a machine can learn characteristics of sounds of elderly peop [...]

Older adults fitted with a cochlear implant to compensate for severe hearing loss have significantly poorer cognitive function than their normal-hearing counterparts. Hearing loss is a risk factor for [...]

Obesity leads to cognitive impairment by activating microglial cells, which consume otherwise functional synapses in the hippocampus, according to a study of male mice. The research suggests that micr [...]

A study finds that neurogenesis -- inducing the production of new neurons -- in the brain structure in which memories are encoded can improve cognitive function in a mouse model of Alzheimer's di [...]

Analysis of data captured during a long-term study of aging adults shows that those who report being very sleepy during the day were nearly three times more likely than those who didn't to have b [...]

Adults both with and without Alzheimer's disease have better cognition skills in the late summer and early fall than in the winter and spring, according to a new study. [...]

Novel strategy shows promise for earlier detection of Alzheimer's diseaseFinding an effective way to identify people with mild cognitive impairment who are most likely to go on to develop Alzheimer's disease has eluded researchers for years. But now, a team of researc [...]

The study analyzed data on stroke and dementia risk from 3.2 million people across the world. The link between stroke and dementia persisted even after taking into account other dementia risk factors [...]

Researchers have discovered that a modified version of an important immune cell protein could be used to treat Alzheimer's disease. The study reveals that soluble versions of a protein called TLR [...]

A clock drawing test for detecting cognitive dysfunction should be conducted routinely in patients with high blood pressure, according to new research. [...]

A new study finds that four out of 10 patients with atrial fibrillation but no history of stroke or transient ischemic attack have previously unknown brain damage. [...]

A psychologist found that carriers of a gene variant that increases the risk for Alzheimer's disease have greater difficulty describing detailed memories of past events. The goal of his research [...]

Alzheimer's one day may be predicted during eye examUsing technology similar to what is found in many eye doctors' offices, researchers have detected evidence suggesting Alzheimer's in older patients who had no symptoms of the disease. [...]

Tau protein accumulation is common across 20 human brain diseases. Researchers have found stressed, senescent cells in Alzheimer's disease, and established a link between tau tangles and this cel [...]

Osteoporosis is estimated to affect 200 million women across the world. In recent decades, several authors have analyzed the impact of osteoporosis on the risk of cognitive decline. [...]

A new study has uncovered why some people that have brain markers of Alzheimer's disease (AD) never develop the classic dementia that others do. The results showed that resilient individuals had [...]

Scientists have suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer's disease, which could provide new avenues for future research. [...]

Older adults who initiate dialysis for kidney failure face a higher likelihood of being diagnosed with dementia and Alzheimer's disease. Certain risk factors were linked this higher risk. Older h [...]

There is new hope for the treatment of Alzheimer's and other neurological diseases following a ground-breaking discovery. [...]

A study of 3,877 randomly selected patients found a significant link between three degenerative eye diseases -- age-related macular degeneration, diabetic retinopathy and glaucoma -- and Alzheimer [...]

Alzheimer's disease and type 2 diabetes: Hope for inhibitors against amyloid plaquesEffective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available. Scientists have now come a little bit closer to a solution: [...]

pH imbalance in brain cells may contribute to Alzheimer's diseaseScientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline -- or pH -- chemistr [...]

A study by researchers investigated lesser-known molecules involved in tauopathies like Alzheimer's. They focused on microRNAs (miRNAs), gene expression regulators that bind to and destroy protei [...]

Alzheimer's drug may stop disease if used before symptoms develop, study suggestsBiologists have gained new understanding of how Alzheimer's disease begins, and how it might be halted using a current medication. [...]

Microfluidic system incorporates neuroinflammation into 'Alzheimer's in a dish' modelBuilding on their development of the first culture system to replicate fully the pathology behind Alzheimer's disease, a research team has now produced a system that includes neuroinflammation, t [...]

Two new studies illustrate that not all forms of amyloid-beta protein -- the protein thought to initiate Alzheimer's disease -- play an equally menacing role in the progress of the disease. Using [...]

Brain discovery could block aging's terrible toll on the mindAging vessels connecting the brain and the immune system play critical roles in both Alzheimer's disease and the decline in cognitive ability that comes with time, new research reveals. By improv [...]

Reduced levels of plasmalogens are associated with an increased risk of Alzheimer's Disease, according to new research. [...]

Two new studies highlight a significant increase in harmful side effects related to the use of commonly prescribed opioid painkillers in people with dementia. Researchers also identified a mechanism t [...]

The first dementia prevalence data from a large population of lesbian, gay and bisexual older adults was reported today. [...]

Increased frontal brain activity in healthy older adults reflects reduced efficiency rather than a way to maintain cognitive function, finds a study of two human samples. The findings contradict a lea [...]

New research highlights sex differences associated with dementia and Alzheimer's disease across the life course, including the first ever large-scale study of reproductive history and dementia ri [...]

Virtual reality technology gives high school students greater insight into what it's like to be someone with suspected mild cognitive impairment, or someone progressing through the continuum of A [...]

Treating dementia with the healing waves of soundUltrasound waves applied to the whole brain improve cognitive dysfunction in mice with conditions simulating vascular dementia and Alzheimer's disease. It is possible that this type of therapy ma [...]

In adults over 70, exposure to general anesthesia and surgery is associated with a subtle decline in memory and thinking skills, according to new research. The study analyzed nearly 2,000 people and f [...]

A new machine-learning model that scans routinely collected NHS data has shown promising signs of being able to predict undiagnosed dementia in primary care. The results from the feasibility study sug [...]

Majority of older adults with probable dementia are likely unaware they have it, study suggestsAn analysis of information gathered for an ongoing and federally sponsored study of aging and disability adds to evidence that a substantial majority of older adults with probable dementia in the Unit [...]

Researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in [...]

One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' now provides a 3D view of brain molecules with 1 [...]

Authors lament the unmet promise of a miracle drug for Alzheimer disease but are heartened by what they see as encouraging improvements in care (care transformation) for a growing population of older [...]

The secret sulfate code that lets the bad Tau inResearchers have uncovered details of how cells invite inside corrupted proteins that can turn normal proteins corrupt, leading to neurodegenerative diseases such as Alzheimer's and Parkinson [...]

Alzheimer's disease is a progressive, neurodegenerative condition that often begins with mild cognitive impairment (MCI), making early and repeated assessments of cognitive change crucial to diag [...]

Herpes linked to Alzheimer's: Antivirals may helpA new commentary on a study by epidemiologists supports the viability of a potential way to reduce the risk of Alzheimer's disease. When the authors looked at subjects who suffered severe herpes [...]

Contact with greenspace is known to have beneficial effects for mental health. A new study suggests that it may also play a positive role against cognitive decline in elderly. In particular, this rese [...]

The 'Big Bang' of Alzheimer's: Scientists ID genesis of diseaseScientists have discovered a 'Big Bang' of Alzheimer's disease -- the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain. [...]

A new study has found the mechanism by which amyloid beta -- the protein deposited into plaques in the brains of patients with Alzheimer's disease -- protects from the effects of herpes viruses c [...]

The workings of memory and learning have yet to be clarified, especially at the neural circuitry level. But researchers have now discovered a specific brain neuron with a central role in learning. The [...]