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We would like to acknowledge and thank the Napier family and friends for their support of the TDRA. Donations were made in memory of Barry Napier, who passed away on March 13, 2017 after a long battle with dementia.

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News

The key to better treatments for brain injuries and disease may lie in the molecules charged with preventing the clumping of specific proteins associated with cognitive decline and other neurological [...]

More evidence for controversial theory that herpesviruses play role in Alzheimer's diseaseIn a large-scale analysis, researchers use data from three different brain banks to suggest that human herpesviruses are more abundant in the brains of Alzheimer's patients and may play a role in [...]

Alzheimer's breakthrough: Brain metals that may drive disease progression revealedAlzheimer's disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition. [...]

The waste-disposal system in a cell can spread harmful protein aggregates between neurons in the brain in Alzheimer's disease. The spread can be reduced in experiments in cultivated cells. The di [...]

A new study indicates that patients with high blood pressure are at a higher risk of developing dementia. This research also shows (for the first time) that an MRI can be used to detect very early sig [...]

People who smoke or have diabetes may be at increased risk of calcifications in a region of the brain crucial to memory, according to a new study. [...]

The rate of decline in certain aspects of memory may be explained by a combination of overall physical fitness and the stiffness of the central arteries. [...]

Researchers reverse cognitive impairments in mice with dementiaReversing memory deficits and impairments in spatial learning is a major goal in dementia research. A lack of knowledge about cellular pathways critical to the development of dementia has prevented si [...]

Active HIV in large white blood cells may drive cognitive impairment in infected miceMacrophages, large white blood cells that engulf and destroy potential pathogens, harbor active viral reserves that appear to play a key role in impaired learning and memory in mice infected with a ro [...]

For more than 20 years, much of the leading research on Alzheimer's has been guided by the 'amyloid hypothesis.' But with a series of failed clinical trials raising questions about this [...]

Dementia, in any form, is a heartbreaking disease that can take away one's thinking and judgement abilities before they pass. To save face, people with dementia often pretend to know answers to q [...]

Short and long daily sleep duration were risk factors for dementia and premature death in a study of Japanese adults aged 60 years and older. [...]

Research has found that some of the genes affected by alcohol and inflammation are also implicated in processes that clear amyloid beta -- the protein that forms globs of plaques in the brain and whic [...]

Innovative new technology will enable people with dementia to receive round the clock observation and live independently in their own homes, a new study reports. [...]

The creation of a map of the molecular network in the aging brain reveals two new Alzheimer's disease target genes. [...]

Recent studies have shown that SuperAgers have less evidence of brain atrophy, have thicker parts of the brain related to memory, and lower prevalence of the pathological changes associated with Alzhe [...]

Hormones affect just about everything that goes on in a woman's body, from reproductive function and sexual libido to weight gain and overall mood. A new study shows how, in the right dosage and [...]

Activation of the immune system by an infection may temporarily disrupt formation of long-term memories in healthy, aging rats by reducing levels of a protein required for brain cells to make new conn [...]

Researchers look at the promising role played by the BMI1 gene, which could someday help mitigate or even reverse the disease. [...]

The tendency of people with dementia to wander and become lost has led researchers to recommend a 'Silver Alert' system, similar to Amber Alerts for missing children, be activated when someo [...]

Psychologists have found a link between depression and an acceleration of the rate at which the brain ages. [...]

New research has found that young people with subtle hearing loss -- the kind they aren't even aware of -- are putting demands on their brains that typically wouldn't be seen until later in [...]

Lifetime risks of developing Alzheimer's disease dementia vary considerably by age, gender and whether any signs or symptoms of dementia are present, according to a new study. [...]

Risk factors for heart disease and stroke appear to hasten the risk of cognitive decline in normal older individuals with evidence of very early Alzheimer's-disease-associated changes in the brai [...]

Moderate to high intensity exercise does not slow cognitive (mental) impairment in older people with dementia, finds a new trial. [...]

Older adults in England with fewer financial resources are more likely to develop dementia, according to new research. [...]

Older people who enjoy a sexually active and emotionally close relationship with their partner tend to perform better at memory tests than sexually inactive older adults on a short-term basis, but thi [...]

Researchers have discovered a mutation that can protect against Alzheimer's disease in mice. The study found that a specific mutation can reduce the characteristic accumulation of the amyloid-bet [...]

Older adults with mild cognitive impairment (MCI), often a precursor to Alzheimer's, showed significant improvement with certain complex thinking and memory skills after exergaming, according to [...]

Could your age, marital status, BMI (body mass index) and amount of sleep impact your risk for dementia? Researchers analyzed data from the Framingham Heart Study (FHS) to identify new combinations of [...]

As the number of adults with Alzheimer's disease and dementia steadily increases, questions around their access to firearms remain largely unaddressed, according to a new study. [...]

Why people become more prone to distraction with ageThe locus coeruleus is a nucleus that controls attention, memory and alertness, but a study shows that it seems to weaken in later years. [...]

Body-worn sensors used at home and in clinic by people with mild Alzheimer's to assess walking could offer a cost-effective way to detect early disease and monitor progression of the illness. [...]

A new study points to a novel potential approach against Alzheimer's disease. In studies in mice, the researchers were able to show that blocking a particular receptor located on astrocytes norma [...]

A new research study provides an explanation for why clinical trials of drugs reducing proteins in the brain that were thought to cause dementia and Alzheimer's have failed. The study has opened [...]

New models could uncover important answers for Alzheimer's researchersAlzheimer's disease currently affects more than 5.5 million Americans and is one of the costliest diseases to treat, according to the Alzheimer's Association. Characterized by a buildup of p [...]

Music activates regions of the brain spared by Alzheimer's diseaseResearchers are looking to the salience network of the brain to develop music-based treatments to help alleviate anxiety in patients with dementia. [...]

Long-term use of some anticholinergic medications are associated with an increased risk of dementia, according to a new study. [...]

Recently, a team of researchers designed a study to learn more about cognitive health and older drivers' crash risks. The study focused on links between levels of cognitive function and crash ris [...]

Researchers found that, in some mild cognitive impairment patients, real neuropsychological stability over a decade is possible and that long-term stability could be predicted based on neuropsychologi [...]

A study of a majority-black cohort finds no clear upward trend in cognitive abilities among older adults. [...]

Detecting Alzheimer's disease before it's too lateThe rate at which the protein beta-amyloid accumulates into the sticky plaques associated with Alzheimer's disease (AD) is already slowing by the time a patient would be considered to have precli [...]

People may be deteriorating into dementia later in life and living with it for a shorter period of time, a new study suggests. [...]

A new computer program can assess whole brain deterioration and help predict cognitive function after stroke up to ten times more accurately than current methods. [...]

A new study proposes that the presence of two beta-amyloid molecules bound together (beta-amyloid dimers) could provide a new biomarker for AD. [...]

Using two complementary approaches to reduce the deposits of amyloid-beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer's dis [...]

Losing just one night of sleep led to an immediate increase in beta-amyloid, a protein in the brain associated with Alzheimer's disease, according to a small, new study. [...]

Studies show that too much sitting, like smoking, increases the risk of heart disease, diabetes and premature death. Researchers found sedentary behavior is linked to thinning in regions of the brain [...]

Inflammatory reactions can change the brain's immune cells in the long term -- meaning that these cells have an 'immunological memory.' This memory may influence the progression of neur [...]

Researchers propose shifting the definition of Alzheimer's disease in living people -- for use in research -- from the current one, based on cognitive changes and behavioral symptoms with biomark [...]