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We would like to acknowledge and thank the Napier family and friends for their support of the TDRA. Donations were made in memory of Barry Napier, who passed away on March 13, 2017 after a long battle with dementia.

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News

In adults over 70, exposure to general anesthesia and surgery is associated with a subtle decline in memory and thinking skills, according to new research. The study analyzed nearly 2,000 people and f [...]

A new machine-learning model that scans routinely collected NHS data has shown promising signs of being able to predict undiagnosed dementia in primary care. The results from the feasibility study sug [...]

Majority of older adults with probable dementia are likely unaware they have it, study suggestsAn analysis of information gathered for an ongoing and federally sponsored study of aging and disability adds to evidence that a substantial majority of older adults with probable dementia in the Unit [...]

Researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in [...]

One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' now provides a 3D view of brain molecules with 1 [...]

Authors lament the unmet promise of a miracle drug for Alzheimer disease but are heartened by what they see as encouraging improvements in care (care transformation) for a growing population of older [...]

The secret sulfate code that lets the bad Tau inResearchers have uncovered details of how cells invite inside corrupted proteins that can turn normal proteins corrupt, leading to neurodegenerative diseases such as Alzheimer's and Parkinson [...]

Alzheimer's disease is a progressive, neurodegenerative condition that often begins with mild cognitive impairment (MCI), making early and repeated assessments of cognitive change crucial to diag [...]

Herpes linked to Alzheimer's: Antivirals may helpA new commentary on a study by epidemiologists supports the viability of a potential way to reduce the risk of Alzheimer's disease. When the authors looked at subjects who suffered severe herpes [...]

Contact with greenspace is known to have beneficial effects for mental health. A new study suggests that it may also play a positive role against cognitive decline in elderly. In particular, this rese [...]

The 'Big Bang' of Alzheimer's: Scientists ID genesis of diseaseScientists have discovered a 'Big Bang' of Alzheimer's disease -- the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain. [...]

A new study has found the mechanism by which amyloid beta -- the protein deposited into plaques in the brains of patients with Alzheimer's disease -- protects from the effects of herpes viruses c [...]

The workings of memory and learning have yet to be clarified, especially at the neural circuitry level. But researchers have now discovered a specific brain neuron with a central role in learning. The [...]

Targeting multiple proteins at once may be the real key to treating neurodegenerative diseases, according to a recent study. [...]

Obstructive sleep apnea is associated with changes to the structure of the brain that are also seen in the early stages of dementia, according to a new study. [...]

Scientists have uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people. Studies with rats found the treatment can reverse changes in blood vessels i [...]

A low-dose aspirin regimen may represent a new avenue for reducing Alzheimer's disease pathology, according to new research in a mouse model. The study identifies a new role for one of the most w [...]

Scientists have been successful in mimicking mechanisms of Alzheimer's disease in a novel, stem cell-based model system that reproduces features of human brain tissue. This experimental tool can [...]

A new study suggests that when a high-fat, high-sugar diet that leads to obesity is paired with normal aging, it may contribute to the development of Alzheimer's disease. In addition, researchers [...]

The key to better treatments for brain injuries and disease may lie in the molecules charged with preventing the clumping of specific proteins associated with cognitive decline and other neurological [...]

More evidence for controversial theory that herpesviruses play role in Alzheimer's diseaseIn a large-scale analysis, researchers use data from three different brain banks to suggest that human herpesviruses are more abundant in the brains of Alzheimer's patients and may play a role in [...]

Alzheimer's breakthrough: Brain metals that may drive disease progression revealedAlzheimer's disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition. [...]

The waste-disposal system in a cell can spread harmful protein aggregates between neurons in the brain in Alzheimer's disease. The spread can be reduced in experiments in cultivated cells. The di [...]

A new study indicates that patients with high blood pressure are at a higher risk of developing dementia. This research also shows (for the first time) that an MRI can be used to detect very early sig [...]

People who smoke or have diabetes may be at increased risk of calcifications in a region of the brain crucial to memory, according to a new study. [...]

The rate of decline in certain aspects of memory may be explained by a combination of overall physical fitness and the stiffness of the central arteries. [...]

Researchers reverse cognitive impairments in mice with dementiaReversing memory deficits and impairments in spatial learning is a major goal in dementia research. A lack of knowledge about cellular pathways critical to the development of dementia has prevented si [...]

Active HIV in large white blood cells may drive cognitive impairment in infected miceMacrophages, large white blood cells that engulf and destroy potential pathogens, harbor active viral reserves that appear to play a key role in impaired learning and memory in mice infected with a ro [...]

For more than 20 years, much of the leading research on Alzheimer's has been guided by the 'amyloid hypothesis.' But with a series of failed clinical trials raising questions about this [...]

Dementia, in any form, is a heartbreaking disease that can take away one's thinking and judgement abilities before they pass. To save face, people with dementia often pretend to know answers to q [...]

Short and long daily sleep duration were risk factors for dementia and premature death in a study of Japanese adults aged 60 years and older. [...]

Research has found that some of the genes affected by alcohol and inflammation are also implicated in processes that clear amyloid beta -- the protein that forms globs of plaques in the brain and whic [...]

Innovative new technology will enable people with dementia to receive round the clock observation and live independently in their own homes, a new study reports. [...]

The creation of a map of the molecular network in the aging brain reveals two new Alzheimer's disease target genes. [...]

Recent studies have shown that SuperAgers have less evidence of brain atrophy, have thicker parts of the brain related to memory, and lower prevalence of the pathological changes associated with Alzhe [...]

Hormones affect just about everything that goes on in a woman's body, from reproductive function and sexual libido to weight gain and overall mood. A new study shows how, in the right dosage and [...]

Activation of the immune system by an infection may temporarily disrupt formation of long-term memories in healthy, aging rats by reducing levels of a protein required for brain cells to make new conn [...]

Researchers look at the promising role played by the BMI1 gene, which could someday help mitigate or even reverse the disease. [...]

The tendency of people with dementia to wander and become lost has led researchers to recommend a 'Silver Alert' system, similar to Amber Alerts for missing children, be activated when someo [...]

Psychologists have found a link between depression and an acceleration of the rate at which the brain ages. [...]

New research has found that young people with subtle hearing loss -- the kind they aren't even aware of -- are putting demands on their brains that typically wouldn't be seen until later in [...]

Lifetime risks of developing Alzheimer's disease dementia vary considerably by age, gender and whether any signs or symptoms of dementia are present, according to a new study. [...]

Risk factors for heart disease and stroke appear to hasten the risk of cognitive decline in normal older individuals with evidence of very early Alzheimer's-disease-associated changes in the brai [...]

Moderate to high intensity exercise does not slow cognitive (mental) impairment in older people with dementia, finds a new trial. [...]

Older adults in England with fewer financial resources are more likely to develop dementia, according to new research. [...]

Older people who enjoy a sexually active and emotionally close relationship with their partner tend to perform better at memory tests than sexually inactive older adults on a short-term basis, but thi [...]

Researchers have discovered a mutation that can protect against Alzheimer's disease in mice. The study found that a specific mutation can reduce the characteristic accumulation of the amyloid-bet [...]

Older adults with mild cognitive impairment (MCI), often a precursor to Alzheimer's, showed significant improvement with certain complex thinking and memory skills after exergaming, according to [...]

Could your age, marital status, BMI (body mass index) and amount of sleep impact your risk for dementia? Researchers analyzed data from the Framingham Heart Study (FHS) to identify new combinations of [...]

As the number of adults with Alzheimer's disease and dementia steadily increases, questions around their access to firearms remain largely unaddressed, according to a new study. [...]